Peter B Crino Selected Research

Malformations of Cortical Development

11/2022	NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold.
1/2021	STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation.
1/2020	Multimodal Analysis of STRADA Function in Brain Development.
11/2019	GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations.
1/2018	DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons.
5/2016	Sending Mixed Signals: The Expanding Role of Molecular Cascade Mutations in Malformations of Cortical Development and Epilepsy.
1/2016	Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3.
4/2015	mTOR signaling in epilepsy: insights from malformations of cortical development.
4/2007	Differential cellular gene expression in ganglioglioma.
3/2002	Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy.

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Peter B Crino Research Topics

Disease

34	Tuberous Sclerosis (Bourneville's Disease) 01/2022 - 12/2002
25	Epilepsy (Aura) 11/2022 - 03/2002
12	Seizures (Absence Seizure) 01/2022 - 03/2002
10	Malformations of Cortical Development 11/2022 - 03/2002
8	Hemimegalencephaly 01/2022 - 04/2002
8	Drug Resistant Epilepsy 01/2022 - 12/2005
8	Focal Cortical Dysplasia 01/2022 - 03/2002
7	Autistic Disorder (Autism) 01/2017 - 12/2002
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2017
5	Neurodevelopmental Disorders 10/2021 - 04/2013
4	Intellectual Disability (Idiocy) 01/2022 - 04/2004
4	Astrocytoma (Pilocytic Astrocytoma) 01/2013 - 05/2003
3	Nervous System Diseases (Neurological Disorders) 01/2020 - 03/2013
3	Inflammation (Inflammations) 01/2016 - 01/2013
2	Starvation 11/2022 - 01/2018
2	Megalencephaly 01/2020 - 11/2019
2	Brain Diseases (Brain Disorder) 01/2018 - 05/2011
2	Gliosis 01/2016 - 08/2003
2	Hypoxia (Hypoxemia) 01/2016 - 01/2011
2	Hamartoma 01/2016 - 01/2010
2	Neurologic Manifestations (Neurological Manifestations) 01/2010 - 11/2008
1	Channelopathies 12/2022
1	Focal cortical dysplasia of Taylor 01/2022
1	Autism Spectrum Disorder 01/2022
1	Neuroinflammatory Diseases 01/2021
1	Psychogenic Nonepileptic Seizures 01/2021
1	Cognitive Dysfunction 01/2021
1	Status Epilepticus (Complex Partial Status Epilepticus) 12/2019
1	Epileptic Syndromes 01/2019
1	Neuroblastoma 01/2018
1	Uniparental Disomy 09/2017
1	Dementia (Dementias) 01/2016
1	Ischemia 01/2016
1	Stroke (Strokes) 01/2016
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2016
1	Partial Epilepsies (Epilepsy, Partial) 05/2015
1	Glioma (Gliomas) 12/2012
1	Hashimoto's encephalitis 05/2011
1	Diabetes Mellitus 05/2011
1	Angiomyolipoma 05/2010
1	Infantile Spasms (West Syndrome) 01/2010
1	Neoplasms (Cancer) 01/2005

Drug/Important Bio-Agent (IBA)

28	trans-sodium crocetinate (crocetin)IBA 01/2022 - 12/2002
15	Proteins (Proteins, Gene)FDA Link 11/2022 - 03/2002
11	Sirolimus (Rapamycin)FDA Link 11/2022 - 12/2007
7	Mechanistic Target of Rapamycin Complex 1IBA 10/2021 - 01/2013
7	MTOR InhibitorsIBA 12/2020 - 04/2015
7	TOR Serine-Threonine KinasesIBA 01/2016 - 01/2011
4	Amino Acids FDA Link 11/2022 - 01/2018
4	Glutamic Acid (Glutamate)FDA Link 08/2012 - 03/2002
3	Phosphotransferases (Kinase)IBA 01/2020 - 11/2003
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2007
3	Biomarkers (Surrogate Marker)IBA 01/2012 - 08/2010
3	AntibodiesIBA 05/2011 - 03/2002
2	PotassiumIBA 08/2012 - 12/2005
2	Semaphorin-3AIBA 09/2007 - 05/2003
2	Messenger RNA (mRNA)IBA 04/2007 - 03/2002
2	Complementary DNA (cDNA)IBA 01/2007 - 04/2005
2	beta CateninIBA 07/2005 - 04/2005
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 12/2022
1	Membrane Transport Proteins (Biological Pump)IBA 11/2022
1	NitrogenIBA 11/2022
1	Cell Adhesion MoleculesIBA 01/2022
1	Biological ProductsIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 12/2020
1	TubulinIBA 05/2016
1	LipopolysaccharidesIBA 01/2016
1	Pharmaceutical PreparationsIBA 05/2015
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2013
1	Receptor for Advanced Glycation End ProductsIBA 01/2013
1	Proto-Oncogene Proteins c-mycIBA 01/2013
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2013
1	Interleukin-8 (Interleukin 8)IBA 01/2012
1	Interleukin-2 (IL2)IBA 01/2012
1	CytokinesIBA 01/2012
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 05/2011
1	Transcription Factors (Transcription Factor)IBA 01/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2011
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2011
1	Epidermal Growth Factor (EGF)IBA 01/2011
1	Hematoxylin (Haematoxylon)IBA 05/2010
1	Eosine Yellowish-(YS) (Eosin)IBA 05/2010
1	Formaldehyde (Formol)FDA Link 05/2010
1	ParaffinIBA 05/2010
1	vesicular GABA transporterIBA 09/2007
1	Fatty Acid-Binding Protein 7IBA 09/2007
1	VimentinIBA 09/2007
1	NestinIBA 04/2007
1	OligonucleotidesIBA 01/2007
1	Glycogen Synthase Kinase 3IBA 04/2005
1	RNA (Ribonucleic Acid)IBA 04/2005
1	Cyclin D1IBA 04/2005
1	Iodized OilIBA 01/2005
1	Ethiodized Oil (Ethiodol)FDA Link 01/2005
1	Ethanol (Ethyl Alcohol)IBA 01/2005
1	Neurotransmitter Receptors (Neurotransmitter Receptor)IBA 12/2004

Therapy/Procedure

2	Therapeutics 01/2019 - 11/2008
2	Precision Medicine 01/2018 - 01/2017
1	Immunomodulation 05/2011